The similarity between these mechanisms and their relation to the general mode of macrolide action is discussed and the discrepancies between currently available data are highlighted Key words macrolides, erythromycin, ketolides, azithromycin, clarithromycin, tylosin, carbomycin, spiramycin, ribosome, resistance INTRODUCTION Antibiotics types based on mechanism of action Drugs and Pharmacology Inhibit cell wall synthesis beta lactams Natural penicillins Penicillin G Penicillin V Benzathine P Procaine P, Penicilllinase R diarrhoea and dyspepsia Erythromycin Clarithromycin Azithromycin Roxithromycin Spiramycin Tylosin TelithromycinErythromycin Antibiotic Class Macrolide Antimicrobial Activity Grampositive bacteria, mycoplasma pneumoniae, chlamydia trachomatis, chlamydia pneumoniae, chlamydia psittaci, ureaplasma urealyticum, legionella pneumophila, campylobacter jejuni, bordatella pertussis Mechanism of Action Macrolides are inhibitors of protein synthesis
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